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陈冠希阿娇高潮10分38秒:热血特种兵再出发,挑战极限!
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陈冠希阿娇高潮10分38秒:热血特种兵再出发,挑战极限!

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热点栏目自选股数据中心行情中心资金流向模拟交易客户端

  中金发布研报称,维持再鼎医药(09688)2025年和2026年盈利预测不变。该行维持跑赢行业评级,基于DCF模型,该行维持H/US股目标价34.41港元/44.24美元不变。4月11日,公司合作伙伴argenx宣布艾加莫德预充针皮下注射剂型获美国FDA批准上市。此外,4月10日,公司也于美国神经病学会公布了艾加莫德ADAPT

  NXT(B阶段数据)与ADAPT-SC+两项研究的长期数据。

  中金主要观点如下:

  艾加莫德3种给药方式将满足各种患者的需求

  本次获FDA批准的艾加莫德预充式皮下注射剂型每次注射20-30秒,由患者、照护人员或医疗卫生专业人士操作,患者在接受皮下注射的指导后可自行给药。艾加莫德预充式皮下注射剂型的获批是基于其与瓶装艾加莫德皮下注射具有生物等效性的研究数据。目前在国内,艾加莫德已有静脉输注和皮下注射2种给药方式,公司将于2025年在国内递交艾加莫德预充式皮下注射剂型的上市申请。

  艾加莫德是治疗gMG的最佳疗法

  根据多项研究,艾加莫德的多项指标具备优势:1)MSE(最小症状表达,MG-ADL≤1分)累计达标率为40%-73%,该指标对患者回归生活有明确指导意义,明显优于竞品;2)起效迅速:用药第1周ADL就有明显改善,ADL改善≥3分第4周就达到73.0%;3)长期疗效持久:3年随访研究(ADAPT+)证明艾加莫德长期反复使用疗效可以长期维持;4)靶向FcRn,选择性降低IgG(不影响IgA/IgM),对免疫系统干预更为精准,感染风险可控,SAE发生率4.8%。总结来看,艾加莫德具备起效更快,疗效更深,达标率高/实现临床双达标,安全性更好,两年独家医保的先发优势。

  公司全年催化剂丰富,多款重磅产品即将读出关键数据

  ZL-1310(DLL3

  ADC)已于2024年公布了积极的ORR数据和安全性数据,公司预计将于1H25公布更多数据,并加速推进ZL-1310单药用于2L+

  ES-SCLC的剂量扩展和1L联合疗法。公司预计Bemarituzumab(FGFR2b)用于治疗1L

  GC/GEJ的全球III期FORTITUDE-101研究将于1H25公布临床数据,随后公司将于1H25在国内递交NDA申请。KarXT已获FDA批准上市,其国内上市申请已于2025年1月获药监局受理,公司预计其有望明年获批,2H25也将读出治疗阿兹海默症引起的精神障碍(ADP)全球III期数据。此外,公司预计将于2025年递交肿瘤电场治疗治疗胰腺癌和非小细胞肺癌的国内上市申请。

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